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Acetate enables metabolic fitness and cognitive performance during sleep disruption

He Q, Ji L, Wang Y, Zhang Y, Wang H, Wang J, Zhu Q, Xie M, Ou W, Liu J, Tang K, Lu K, Liu Q, Zhou J, Zhao R, Cai X, Li N, Cao Y, Li T. Acetate enables metabolic fitness and cognitive performance during sleep disruption. Cell Metab. 2024 Aug 12:S1550-4131(24)00290-0. doi: 10.1016/j.cmet.2024.07.019. Epub ahead of print. PMID: 39163862.

GBA-AAV mitigates sleep disruptions and motor deficits in mice with REM sleep behavior disorder

Chen Y, Xie WY, Xia D, Zhang MT, Sun YR, Duan WX, Shen Y, Wang F, Qu WM, Huang ZL, Liu CF. GBA-AAV mitigates sleep disruptions and motor deficits in mice with REM sleep behavior disorder. NPJ Parkinsons Dis. 2024 Aug 2;10(1):142. doi: 10.1038/s41531-024-00756-5. PMID: 39095359; PMCID: PMC11297138.

40 Hz light flickering facilitates the glymphatic flow via adenosine signaling in mice

Sun X, Dias L, Peng C, Zhang Z, Ge H, Wang Z, Jin J, Jia M, Xu T, Guo W, Zheng W, He Y, Wu Y, Cai X, Agostinho P, Qu J, Cunha RA, Zhou X, Bai R, Chen JF. 40 Hz light flickering facilitates the glymphatic flow via adenosine signaling in mice. Cell Discov. 2024 Aug 6;10(1):81. doi: 10.1038/s41421-024-00701-z. PMID: 39103336; PMCID: PMC11300858.

Dexmedetomidine Promotes NREM Sleep by Depressing Oxytocin Neurons in the Paraventricular Nucleus in Mice

Zhang Y, Li J, Li Y, Wang W, Wang D, Ding J, Wang L, Cheng J. Dexmedetomidine Promotes NREM Sleep by Depressing Oxytocin Neurons in the Paraventricular Nucleus in Mice. Neurochem Res. 2024 Jul 30. doi: 10.1007/s11064-024-04221-w. Epub ahead of print. PMID: 39078522.

Propofol improves sleep deprivation-induced sleep structural and cognitive deficits via upregulating the BMAL1 expression and suppressing microglial M1 polarization

Liu H, Yang C, Wang X, Yu B, Han Y, Wang X, Wang Z, Zhang M, Wang H. Propofol improves sleep deprivation-induced sleep structural and cognitive deficits via upregulating the BMAL1 expression and suppressing microglial M1 polarization. CNS Neurosci Ther. 2024 Jul;30(7):e14798. doi: 10.1111/cns.14798. PMID: 39015099; PMCID: PMC11252557.

Analysis of norepinephrine-regulated cerebral lymphatic drainage by the second near-infrared region in vivo imaging

Xi Li, Tianhao Yang, Zhongyang Zhang, Shengnan Wu, Zhen Yuan, Feifan Zhou; Analysis of norepinephrine-regulated cerebral lymphatic drainage by the second near-infrared region in vivo imaging. APL Photonics 1 July 2024; 9 (7): 070801. https://doi.org/10.1063/5.0205571

Mice harboring the T316N variant in the GABAAR γ2 subunit exhibit sleep-related hypermotor epilepsy phenotypes and hypersynchronization in the thalamocortical pathway

Jiang YL, Xia L, Zhao JJ, Zhou HM, Mi D, Wang X, Wang YY, Song CG, Jiang W. Mice harboring the T316N variant in the GABAAR γ2 subunit exhibit sleep-related hypermotor epilepsy phenotypes and hypersynchronization in the thalamocortical pathway. Exp Neurol. 2024 Apr 9;376:114775. doi: 10.1016/j.expneurol.2024.114775. Epub ahead of print. PMID: 38604438.

Dexmedetomidine promotes NREM sleep by depressing the neuronal activity of OXT neurons in the PVN

Zhang Y, Li J, Wang W, et al. Dexmedetomidine promotes NREM sleep by depressing the neuronal activity of OXT neurons in the PVN. Research Square; 2024. DOI: 10.21203/rs.3.rs-4207174/v1.

40 Hz light flickering promotes sleep through cortical adenosine signaling

Zhou X, He Y, Xu T, Wu Z, Guo W, Xu X, Liu Y, Zhang Y, Shang H, Huang L, Yao Z, Li Z, Su L, Li Z, Feng T, Zhang S, Monteiro O, Cunha RA, Huang ZL, Zhang K, Li Y, Cai X, Qu J, Chen JF. 40 Hz light flickering promotes sleep through cortical adenosine signaling. Cell Res. 2024 Feb 8. doi: 10.1038/s41422-023-00920-1. Epub ahead of print. PMID: 38332199.

Microglia facilitate and stabilize the response to general anesthesia via modulating the neuronal network in a brain region-specific manner

He Y, Liu T, He Q, Ke W, Li X, Du J, Deng S, Shu Z, Wu J, Yang B, Wang Y, Mao Y, Rao Y, Shu Y, Peng B. Microglia facilitate and stabilize the response to general anesthesia via modulating the neuronal network in a brain region-specific manner. Elife. 2023 Dec 22;12:RP92252. doi: 10.7554/eLife.92252. PMID: 38131301; PMCID: PMC10746144.

Overexpression of Sirt6 ameliorates sleep deprivation induced-cognitive impairment by modulating glutamatergic neuron function

Zhu J, Chen C, Li Z, Liu X, He J, Zhao Z, He M, Nie B, Liu Z, Chen Y, Su K, Li X, Chen J, Xiang H, Xu F, Lin K, Zhang Z, Wang J. Overexpression of Sirt6 ameliorates sleep deprivation induced-cognitive impairment by modulating glutamatergic neuron function. Neural Regen Res. 2023 Nov;18(11):2449-2458. doi: 10.4103/1673-5374.371370. PMID: 37282476; PMCID: PMC10360083.

Effects of propofol and sevoflurane on social and anxiety-related behaviours in sleep-deprived rats

Zhu J, Chen C, Wu J, He M, Li S, Fang Y, Zhou Y, Xu H, Sadigh-Eteghad S, Manyande A, Zheng F, Chen T, Xu F, Ma D, Wang J, Zhang Z. Effects of propofol and sevoflurane on social and anxiety-related behaviours in sleep-deprived rats. Br J Anaesth. 2023 Sep;131(3):531-541. doi: 10.1016/j.bja.2023.05.025. Epub 2023 Aug 4. PMID: 37543435.

Reducing complement activation during sleep deprivation yields cognitive improvement by dexmedetomidine

Zhai Q, Zhang Y, Ye M, Zhu S, Sun J, Wang Y, Deng B, Ma D, Wang Q. Reducing complement activation during sleep deprivation yields cognitive improvement by dexmedetomidine. Br J Anaesth. 2023 Sep;131(3):542-555. doi: 10.1016/j.bja.2023.04.044. Epub 2023 Jul 29. PMID: 37517957.

SAG treatment ameliorates memory impairment related to sleep loss by upregulating synaptic plasticity in adolescent mice

Gao C, Cao Y, He M, Zhang X, Zhong Q, Tang L, Chen T, Zhang Z. SAG treatment ameliorates memory impairment related to sleep loss by upregulating synaptic plasticity in adolescent mice. Behav Brain Res. 2023 Jul 26;450:114468. doi: 10.1016/j.bbr.2023.114468. Epub 2023 May 5. PMID: 37148913.

PER2 integrates circadian disruption and pituitary tumorigenesis

Guo L, Cen H, Weng J, He Y, Guo X, He D, Liu K, Duan S, Yang J, Zhang X, Qin Z, Wan Y, Chen Z, Wu B. PER2 integrates circadian disruption and pituitary tumorigenesis. Theranostics. 2023 Apr 29;13(8):2657-2672. doi: 10.7150/thno.82995. PMID: 37215573; PMCID: PMC10196825.

P2X7 receptor-activated microglia in cortex is critical for sleep disorder under neuropathic pain

Li T, Gao Y, He M, Gui Z, Zhao B, Cao Y, Chen T, Zhu J, Wang J, Zhong Q, Zhang Z. P2X7 receptor-activated microglia in cortex is critical for sleep disorder under neuropathic pain. Front Neurosci. 2023 Feb 3;17:1095718. doi: 10.3389/fnins.2023.1095718. PMID: 36816134; PMCID: PMC9936193.

Crossing nerve transfer drives sensory input-dependent plasticity for motor recovery after brain injury

Gao Z, Pang Z, Lei G, Chen Y, Cai Z, Zhu S, Lin W, Qiu Z, Wang Y, Shen Y, Xu W. Crossing nerve transfer drives sensory input-dependent plasticity for motor recovery after brain injury. Sci Adv. 2022 Sep 2;8(35):eabn5899. doi: 10.1126/sciadv.abn5899. Epub 2022 Aug 31. PMID: 36044580; PMCID: PMC9432844.

E4BP4 Coordinates Circadian Control of Cognition in Delirium

Chen M, Zhang L, Shao M, Du J, Xiao Y, Zhang F, Zhang T, Li Y, Zhou Q, Liu K, Wang Z, Wu B. E4BP4 Coordinates Circadian Control of Cognition in Delirium. Adv Sci (Weinh). 2022 Aug;9(23):e2200559. doi: 10.1002/advs.202200559. Epub 2022 Jun 17. PMID: 35713240; PMCID: PMC9376827.